I do not see any major problems with every setting maxed (2560×1440) on the biggest map except for some stuttering when I follow a vehicle (clicking on the x in the vehicle window) at almost horizontal angle. I do not know if there is a 32-bit version of this game, I would suppose it can run into problems on a 32-bit OS.
My system is about a year old, Core i7 4770 (Haswell) with 32GB RAM and a GTX 770.
This is for the period 1850-1880, though. May run into problems later on, I guess.