I concur with the ideas about stations being alot more flexible. I find alot of the time spent in the game revolves around these structures in one way or another, so it makes sense to have them flexible and detailed, from a rural stop, to a grand terminus.
I would also like to see the disappearance of the truck depots, and instead have the industry connected to the road (they virtually require that anyway), and the trucks call at the industry to pick up/drop off stuff. Truck depots at the city? sure, but not industries.
And lastly, some sort of ‘research’ element – sort of a ‘build your own style engines/wagons’, rather than simply waiting for things to drop in for use by the general public, often not being what you want anyway.