In 1850 yes. Trucks (Horse Wagons) are a bit too slow for long distance travel until the first gasoline-powered ones in the 1900s as you usually lose more money than you gain initially. If you are going to use trucks to start then only use them on routes where cargo is already moving on its own: this will alow for you to already have a supply of cargo to load with and will automatically increase production immediately after a few trucks arrive at their destination(s).
Sametime applies with buses (Horse wagons), but the initial profits are lower for local travel then long distance travel. Trams (Horse trams) seem to be better at local then buses initally, but are more expensive to build.
Allow these tips also apply to the Euro and Nordic (Fan made) Dlc.